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Introduction to the whole process of CAR-T cell clinical treatment: Taking lymphoma as an exampleAs of April 16, 2021, there are 2,073 cell therapy drugs under development worldwide, of which CAR-T therapies account for 1,164, dominating the market with an ...05-30 -
In-depth assessment of the development process of CRS - providing the best intervention window and rChimeric antigen receptor-modified T cell (CAR-T) therapy is currently a powerful approach to combat hematological malignancies, but cytokine release syndrome (...05-30 -
Anti-cancer effects of NK from different sources such as peripheral blood and umbilical cord bloodIntroduction In the minds of most people today, cancer is still an incurable disease. Both the illness experience and the traditional treatment process are v...05-16 -
Off-the-shelf CAR-T cell therapy against host immune rejectionIn recent years, CAR-T cell therapy has become a promising cancer treatment. However, due to the high cost of CAR-T therapy and the differences in patients'...05-15 -
Comparison of CAR-NK cells derived from adult peripheral blood and umbilical cord bloodAmong hematological cancers, acute lymphoblastic leukemia (ALL) and chronic lymphocytic leukemia (CLL) are the most common leukemias in children and the elderly...05-15 -
Safety, efficacy, and determinants of allogeneic CAR-NK cell therapy for tumors: a phase 1/2 trialCAR-T cell therapy marks the advent of the era of cell therapy. However, CAR-T cells have their limitations, including treatment costs, manufacturing time, and ...05-15 -
Small extracellular vesicles derived from solid tumors inhibit the efficacy of CAR-T cellsChimeric antigen receptor T-cell ( CAR-T ) therapy has shown significant efficacy in the treatment of hematopoietic tumors. However, their effectiveness in trea...05-15 -
NKG2D-CAR T cell anti-aging researchThe reason why humans die is that exhausted tissues cannot renew themselves forever, and the ability of cells to divide is also limited. Aging is a problem that...05-15 -
CAR T targeting intracellular oncoproteinsCAR - T cell tumor immunotherapy has demonstrated strong anti-tumor efficacy in hematological tumors such as leukemia, but its application in the field of solid...05-15 -
Limitations and breakthrough directions of CAR-T in the treatment of solid tumorsThe incidence and mortality of cancer continue to increase, but effective treatments have not yet been found. Traditional therapies, including surgery, radiothe...05-15 -
Study on CD123-targeted CAR-T cells for the treatment of AMLCAR-T cell therapy is an immunotherapy method that uses genetic engineering technology to modify human T cells so that they can specifically recognize and kill ...05-15 -
CRISPR screening reveals the role of BHLHE40 in mimicking CD8+ T cell exhaustion in vitroT cell exhaustion is a state in which T cells lose function under long-term stimulation of chronic infection and cancer. Its main manifestations are: reduced ...05-15 -
Neuropathic pain—one of the potential clinical applications of NK cellsNeuropathic pain refers to pain directly caused by some injury or disease affecting the somatosensory system. Peripheral neuropathy causing pain may result from...04-19 -
Retroviral VectorThe MMLV retroviral gene expression vector system is a highly efficient system that stably integrates foreign genes into mammalian cell genomes, and is also a p...04-01 -
Application of cellular immunotherapy in autoimmune diseasesAutoimmune diseases (ADs) are a class of diseases that are caused by autoimmune tolerance disorder and the body's immune response to the autoimmune antigen,...04-08 -
Lentivirus vectorThe lentiviral vector system is a very efficient vector tool for the stable integration of foreign genes into mammalian cells. In addition to conventional plas...04-03 -
Anti-aging health care -- one of clinical applications of NK cellsNK cells are the core participants in senescent cell immune surveillance. They increase with age, but their cytotoxicity and function continue to decline, which...04-08 -
Adeno-associated virus vectorAdenoviral vectors efficiently transduce the majority of mammalian cells and exist in host cells as free DNA. This vector system is a preferred method for intro...04-08 -
Research progress of universal cell therapyCAR-T cell therapy brings new hope to cancer patients with its unique targeted therapy. The 10 CAR-T drugs currently on the market are mainly autologous CAR-T c...04-08 -
Mammalian gene expression vectorsIn the biomedical field, the use of conventional transfection to transfer plasmid vectors into mammalian cells is the most widely used method.Although many more...04-03 -
Metabolic challenges in CAR-T cell therapyCAR-T cell therapy has already shown great success in treating advanced hematologic malignancies. However, its efficacy in solid tumors has been unsatisfactory,...04-08 -
Chimeric vectorsAdeno-associated virus(AAV) is widely used in gene transduction experiments both in vivo and in vitro. AAV can infect a large variety of mammalian cells, produc...04-08 -
A new strategy to enhance anti-tumor activity and persistence: reducing CAR-T cell methylation levelDNA methylation refers to the change of specific bases in the DNA sequence at the C-5 position of cytosine, the N-6 position of adenine and the chromium positio...04-08 -
VSV virus vectorVesicular stomatitis virus (VSV) vectors are widely used in studying the invasion of viral particles into host cells, identifying cell surface receptors that me...04-08 -
Shenzhen Cell Valley achieved a major breakthrough in CAR-NK preparation processIn response to the pain points in the early R&D and industrial production of CAR-NK cells, Shenzhen Cell Valley's core R&D team conducted long-term ...04-17 -
Application of safety switch in cell therapy1、Safety switch of cell therapy After autologous or allogeneic cell infusion, a large number of immune cells are activated and prolifed rapidly, resulting in e...04-17 -
CRISPR/CAS9 technology in the field of cell therapy1、Introduction to CRISPR/Cas system CRISPR (Clustered Regularly Interspaced Short Palindromic Repeat), first discovered in the late 1980s, is an unusual geneti...04-17 -
Research on the safety of viral vectors1、Introduction Viral vectors are the most popular delivery method for cell therapy and gene therapy. In cell and gene therapy, viral vectors expressing anti-tu...04-17 -
Viral and non-viral vectors in CAR-T cell therapy1、Introduction Currently, the most commonly used CAR-T cell construction methods mainly include three categories: viral vectors represented by retroviruses and...04-17 -
Key raw materials for cell therapy—viral vectors1、Introduction Gene transfection technology is a key link in cell therapy. It refers to delivering plasmid DNA containing target genes to cells and expressing ...04-17 -
Research progress on CAR-T therapy for multiple myelomaMultiple myeloma (MM) is a malignant proliferative tumor of plasma cells characterized by the abnormal accumulation of monoclonal plasma cells in the bone marro...04-17 -
Current status of cell therapy research1、Overview of cell therapy Cell therapy refers to the transplantation or infusion of normal or bioengineered human cells into patients. The newly imported cell...04-17 -
CAR-T cell immunotherapy for the treatment of acute myeloid leukemiaQuotation Acute myeloid leukemia (AML) is a malignant tumor caused by clonal proliferation and differentiation disorders of bone marrow hematopoietic stem cell...04-02
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